Article
Werner syndrome: studies in an affected family reveal a cellular phenotype of unaffected siblings.
Mechanisms of ageing and development - 5 Jul 1996
Weirich H G, Weirich-Schwaiger H, Kofler H, Sidoroff A, Fritsch P, Schachtschabel D O, Schweiger M, Hirsch-Kauffmann M
Abstract excerpt
Werner syndrome is an inherited disease with symptoms of presenescence. The primary defect site either on the protein or at the DNA level is not known, nor is it possible to identify a heterozygous phenotype. On the basis of cellular peculiarities expressed in the homozygotes-lifespan reduction of cells in culture, length of population doubling time and chromosomal instability-we searched for a 'Werner-like'...
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