Article
The gene responsible for Werner syndrome may be a cell division "counting" gene.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1993
Faragher R G, Kill I R, Hunter J A, Pope F M, Tannock C, Shall S
Abstract excerpt
Werner syndrome is a rare, autosomal, recessive condition that is frequently studied as a model of some aspects of human aging, although the behavioral changes that are usually associated with old age are only seen very infrequently. A most striking aspect of the phenotype of Werner syndrome, presumably arising from the same gene defect, is a dramatic shortening of the replicative life-span of dermal fibroblasts...
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