Werner syndrome: a molecular genetic hypothesis.

Abstract excerpt

On the basis of clinical and experimental observations, we postulate that the primary genetic abnormality in Werner syndrome (WS) is mutation in a gene encoding a trans-acting factor that normally represses a second genetic locus or its product, an inhibitor of DNA synthesis elaborated when cells reach the end of their replicative life span. The result is early derepression of this second locus, leading to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA
• Share to Genes, Regulator
• Share to Mutation