Werner syndrome: a molecular genetic hypothesis.

doi:10.1093/geronj/45.1.b3

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Article

Werner syndrome: a molecular genetic hypothesis.

Journal of gerontology - 1 Jan 1990

Goldstein S, Murano S, Shmookler Reis R J

Abstract excerpt

On the basis of clinical and experimental observations, we postulate that the primary genetic abnormality in Werner syndrome (WS) is mutation in a gene encoding a trans-acting factor that normally represses a second genetic locus or its product, an inhibitor of DNA synthesis elaborated when cells...

Topics

DNA
Genes, Regulator
Humans
Mutation
Werner Syndrome

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