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Article

Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).

The Journal of physiology - 1 Jul 2001

Aydar E, Palmer C

Abstract excerpt

1. In the present study the functional role of the C-terminus of the human ether-à-go-go-related gene K(+) channel HERG was investigated using a series of C-terminal deletion constructs expressed in Xenopus oocytes. 2. Constructs with deletions of 311 or more amino acid residues failed to form functional channels. Truncation by 215 amino acid residues or fewer had no discernable effects on channel activity....

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Source

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Identifiers

PMID: 11432987
DOI: 10.1111/j.1469-7793.2001.t01-3-00001.x
PMCID: PMC2278693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).PMID 11432987Read ↗

Identification of a COOH-terminal segment involved in maturation and stability of human ether-a-go-go-related gene potassium channels.Semantic proximity Read ↗

Clinical and electrophysiological characterization of a novel mutation R863X in HERG C-terminus associated with long QT syndrome.Semantic proximity Read ↗

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus.Semantic proximity Read ↗

Characterization of S818L mutation in HERG C-terminus in LQT2. Modification of activation-deactivation gating properties.Semantic proximity Read ↗

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.Semantic proximity Read ↗

A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Semantic proximity Read ↗

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.Semantic proximity Read ↗

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.Semantic proximity Read ↗

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.Semantic proximity Read ↗

Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.Semantic proximity Read ↗

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