Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.

Biophysical journal - 3 Aug 2011

Es-Salah-Lamoureux Zeineb, Xiong Ping Yu, Goodchild Samuel J, Ahern Christopher A, Fedida David

Abstract excerpt

G628S is a mutation in the signature sequence that forms the selectivity filter of the human ether-a-go-go-related gene (hERG) channel (GFG) and is associated with long-QT2 syndrome. G628S channels are known to have a dominant-negative effect on hERG currents, and the mutant is therefore thought to be nonfunctional. This study aims to assess the physiological mechanism that prevents the surface-expressing G628S...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electric Conductivity
Share to ERG1 Potassium Channel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ether-A-Go-Go Potassium Channels

Share to Intracellular Space

Share to Permeability

Share to Potassium

Share to Sodium

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 21806934
DOI: 10.1016/j.bpj.2011.06.028
PMCID: PMC3145283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.PMID 21806934Read ↗

Na+ permeation and block of hERG potassium channels.Semantic proximity Read ↗

Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant.Semantic proximity Read ↗

A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Semantic proximity Read ↗

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.Semantic proximity Read ↗

Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels.Semantic proximity Read ↗

[K(+)](o)-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotype.Semantic proximity Read ↗

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.Semantic proximity Read ↗

The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C.Semantic proximity Read ↗

Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function.Semantic proximity Read ↗

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.Semantic proximity Read ↗

Potassium dependent structural changes in the selectivity filter of HERG potassium channelsSemantic proximity Read ↗

Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.