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Article

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.

The Journal of physiology - 15 Jul 2004

Subbiah Rajesh N, Clarke Catherine E, Smith David J, Zhao JingTing, Campbell Terence J, Vandenberg Jamie I

Abstract excerpt

The human ether-á-go-go related gene (HERG) encodes the pore forming alpha-subunit of the rapid delayed rectifier K(+) channel which is central to the repolarization phase of the cardiac action potential. HERG K(+) channels have unusual kinetics characterized by slow activation and deactivation, yet rapid inactivation. The fourth transmembrane domain (S4) of HERG, like other voltage-gated K(+) channels, contains...

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Identifiers

PMID: 15181157
DOI: 10.1113/jphysiol.2004.062588
PMCID: PMC1664982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.PMID 15181157Read ↗

Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.Semantic proximity Read ↗

The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C.Semantic proximity Read ↗

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Semantic proximity Read ↗

hERG K(+) channels: structure, function, and clinical significance.Semantic proximity Read ↗

Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.Semantic proximity Read ↗

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function.Semantic proximity Read ↗

A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Semantic proximity Read ↗

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.Semantic proximity Read ↗

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.Semantic proximity Read ↗

Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.Semantic proximity Read ↗

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