Article
A novel transcriptional suppressor located within a downstream intron of the BCR gene.
The Journal of biological chemistry - 8 Apr 1994
Stewart M J, Cox G, Reifel-Miller A, Kim S Y, Westbrook C A, Leibowitz D S
Abstract excerpt
A reciprocal translocation between chromosomes 9 and 22 creates the Philadelphia (Ph1) chromosome in chronic myelogenous leukemia. This translocation results in the fusion of the ABL and the BCR genes to form a BCR/ABL fusion gene, the product of which has a greatly increased protein tyrosine kinase activity in comparison with the normal ABL protein. The chromosome 22 translocation breakpoints are concentrated...
Topics
- Base Composition
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- Fusion Proteins, bcr-abl
- Gene Expression Regulation
- HeLa Cells
- Humans
- Introns
- Molecular Sequence Data