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Article

A novel transcriptional suppressor located within a downstream intron of the BCR gene.

The Journal of biological chemistry - 8 Apr 1994

Stewart M J, Cox G, Reifel-Miller A, Kim S Y, Westbrook C A, Leibowitz D S

Abstract excerpt

A reciprocal translocation between chromosomes 9 and 22 creates the Philadelphia (Ph1) chromosome in chronic myelogenous leukemia. This translocation results in the fusion of the ABL and the BCR genes to form a BCR/ABL fusion gene, the product of which has a greatly increased protein tyrosine kinase activity in comparison with the normal ABL protein. The chromosome 22 translocation breakpoints are concentrated...

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Identifiers

PMID: 8144670

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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