Article
Differential regulation of three members of the ATF/CREB family of DNA-binding proteins.
Oncogene - 1 Nov 1991
Flint K J, Jones N C
Abstract excerpt
The ATF/CRE binding site can mediate transcriptional activation by cAMP, the adenovirus E1A protein and the human T-cell leukaemia virus 1 (HTLV1) tax protein. A large number of different proteins bind specifically to this element either as homodimers or as heterodimers. Using GAL4-ATF/CREB fusions, we have investigated the regulatory functions of three members of this family. CREB1 (CREB) is strongly activated...
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