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Article

RAD51 is essential for spermatogenesis and male fertility in mice

15 Mar 2022

Abstract excerpt

Abstract The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous recombination (HR) during both mitosis and meiosis. However, the physiological role of RAD51 during spermatogenesis remains unclear since RAD51 null mutation is embryonic lethal in mice. In this study, we generated a conditional knockout mouse model to study the role of RAD51 in spermatogenesis. Conditional disruption of RAD51...

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PMID: 35292640
DOI: 10.1038/s41420-022-00921-w

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