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Article

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.

Current biology : CB - 14 Dec 2004

Turner James M A, Aprelikova Olga, Xu Xiaoling, Wang Ruihong, Kim Sangsoo, Chandramouli Gadisetti V R, Barrett J Carl, Burgoyne Paul S, Deng Chu-Xia

Abstract excerpt

In mammalian spermatogenesis, the X and Y chromosomes are transcriptionally silenced during the pachytene stage of meiotic prophase (meiotic sex chromosome inactivation, MSCI), forming a condensed chromatin domain termed the sex or XY body. The nucleosomal core histone H2AX is phosphorylated within the XY chromatin domain just prior to MSCI, and it has been hypothesized that this triggers the chromatin...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 15589157
DOI: 10.1016/j.cub.2004.11.032

Genes

ATR
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.PMID 15589157Read ↗

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