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Article

Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant.

Molecular reproduction and development - 1 Jul 2003

Escalier Denise, Bai Xi-Yuan, Silvius Derek, Xu Pin-Xian, Xu Xin

Abstract excerpt

Ube2b (yeast Ubc2b/Rad6 homolog) null mice were described previously. Ube2b encodes the murine ubiquitin conjugating enzyme mHR6B. Ube2b(-/-) mice were shown to present male infertility and their sperm head shape anomalies suggested that Ube2b may be involved in the replacement of nuclear proteins during spermatid chromatin condensation. Apoptosis of spermatocytes suggested additional targets of Ube2b during...

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PMID: 12784252
DOI: 10.1002/mrd.10290

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