Article
Role of the chicken homeobox-containing genes GHox-4.6 and GHox-8 in the specification of positional identities during the development of normal and polydactylous chick limb buds.
Development (Cambridge, England) - 1 Jun 1992
Coelho C N, Upholt W B, Kosher R A
Abstract excerpt
During early stages of normal chick limb development, the homeobox-containing (HOX) gene GHox-4.6 is expressed throughout the posterior mesoderm of the wing bud from which most of the skeletal elements including the digits will develop, whereas GHox-8 is expressed in the anterior limb bud mesoderm which will not give rise to skeletal elements. In the present study, we have examined the expression of GHox-4.6 and...
Topics
- Animals
- Chick Embryo
- Congenital Abnormalities
- Extremities
- Gene Expression
- Genes, Homeobox
- Mesoderm
- Molecular Probe Techniques
- Morphogenesis
- Mutation