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Article

Statistical genetics of normal variation in family data for oligogenic diseases.

Genetic epidemiology - 1 Jan 1995

Mahaney M C, Jaquish C E, Comuzzie A G

Abstract excerpt

A quadrivariate quantitative genetic analysis detected significant heritabilities for four simulated quantitative traits (Q1-Q4) with additive genetic pleiotropy between traits Q1, Q2, and Q3. Using univariate segregation analysis, we tentatively detected five major loci: one each for Q2, Q3, and Q4 and two, at different maxima, for Q1. Bivariate one-locus segregation analysis identified significant major locus...

Topics

Alleles
Analysis of Variance
Chi-Square Distribution
Chromosome Mapping
Computer Simulation
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genetic Testing
Genotype
Linear Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Nuclear Family

Polymorphism, Genetic

Source

Identifiers

PMID: 8788009
DOI: 10.1002/gepi.1370120642

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