Article
Mapping quantitative effects of oligogenes by allelic association.
Annals of human genetics - 1 May 2002
Zhang W, Collins A, Abecasis G R, Cardon L R, Morton N E
Abstract excerpt
Regression analysis of a quantitative trait as a function of a single diallelic polymorphism has been extended to allelic association by composite likelihood under the Malecot model for multiple markers. We applied the method to 10 single nucleotide polymorphisms (SNPs) spanning 27 kb of the angiotensin-I converting enzyme (ACE) gene in British families, localising a causal SNP between G2530A and 4656(CT)3/2 in...
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