A multivariate approach to affected-sib-pair analysis using highly dense molecular maps.

doi:10.1002/(SICI)1098-2272(1997)14:6<761::AID-GEPI33>3.0.CO;2-M

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Article

A multivariate approach to affected-sib-pair analysis using highly dense molecular maps.

Genetic epidemiology - 1 Jan 1997

Bailey J N, Palmer C G, Woodward J A, Smalley S L

Abstract excerpt

A multivariate approach to affected-sib-pair analyses was performed to localize disease-susceptibility genes with a minimum number of type I errors (false positives). Using 1,155 independent affected sib pairs extracted from Problem 2A of the GAW10 data set, we were able to localize major genes (...

Topics

Computer Simulation
Female
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Humans
Male
Matched-Pair Analysis
Models, Genetic
Multivariate Analysis
Nuclear Family
Predictive Value of Tests

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