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Article

Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models.

Genetic epidemiology - 1 May 2015

Wang Yifan, Liu Aiyi, Mills James L, Boehnke Michael, Wilson Alexander F, Bailey-Wilson Joan E, Xiong Momiao, Wu Colin O, Fan Ruzong

Abstract excerpt

In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze the phenotypic traits separately using univariate analyses and combine the test results through multiple comparisons. This approach may lead to low power. Multivariate functional linear models are developed to connect genetic variant data to multiple quantitative traits adjusting...

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Identifiers

PMID: 25809955
DOI: 10.1002/gepi.21895
PMCID: PMC4443751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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