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Genetic correlations of polygenic disease traits: from theory to practice.

Nature reviews. Genetics - 1 Oct 2019

van Rheenen Wouter, Peyrot Wouter J, Schork Andrew J, Lee S Hong, Wray Naomi R

Abstract excerpt

The genetic correlation describes the genetic relationship between two traits and can contribute to a better understanding of the shared biological pathways and/or the causality relationships between them. The rarity of large family cohorts with recorded instances of two traits, particularly disease traits, has made it difficult to estimate genetic correlations using traditional epidemiological approaches....

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PMID: 31171865
DOI: 10.1038/s41576-019-0137-z

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