pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor.

doi:10.1110/ps.0230103

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Article

pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor.

Protein science : a publication of the Protein Society - 1 May 2003

Ricci Margaret Speed, Sarkar Casim A, Fallon Eric M, Lauffenburger Douglas A, Brems David N

Abstract excerpt

After a cytokine binds to its receptor on the cell surface (pH approximately 7), the complex is internalized into acidic endosomal compartments (pH approximately 5-6), where partially unfolded intermediates can form. The nature of these structural transitions was studied for wild-type interleukin-2 (IL-2) and wild-type granulocyte colony-stimulating factor (G-CSF). A noncoincidence of denaturation transitions in...

Topics

Endocytosis
Granulocyte Colony-Stimulating Factor
Guanidine
Humans
Hydrogen-Ion Concentration
Interleukin-2
Mutation
Protein Conformation
Protein Denaturation
Protein Structure, Secondary
Protein Transport

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PMID: 12717025
DOI: 10.1110/ps.0230103
PMCID: PMC2323873

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