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Article

Characterization of Salt-Induced Oligomerization of Human β2-Microglobulin at Low pH.

The journal of physical chemistry. B - 18 Aug 2016

Narang Dominic, Singh Anubhuti, Swasthi Hema M, Mukhopadhyay Samrat

Abstract excerpt

Misfolding and amyloid aggregation of human β2-microglobulin (β2m) have been linked to dialysis-related amyloidosis. Previous studies have shown that in the presence of different salt concentrations and at pH 2.5, β2m assembles into aggregates with distinct morphologies. However, the structural and mechanistic details of the aggregation of β2m, giving rise to different morphologies, are poorly understood. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27467899
DOI: 10.1021/acs.jpcb.6b05619

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