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Article

Next-Generation Bacillus anthracis Live Attenuated Spore Vaccine Based on the htrA(-) (High Temperature Requirement A) Sterne Strain.

Scientific reports - 6 Jan 2016

Chitlaru Theodor, Israeli Ma'ayan, Bar-Haim Erez, Elia Uri, Rotem Shahar, Ehrlich Sharon, Cohen Ofer, Shafferman Avigdor

Abstract excerpt

Anthrax is a lethal disease caused by the gram-positive spore-producing bacterium Bacillus anthracis. Live attenuated vaccines, such as the nonencapsulated Sterne strain, do not meet the safety standards mandated for human use in the Western world and are approved for veterinary purposes only. Here we demonstrate that disrupting the htrA gene, encoding the chaperone/protease HtrA (High Temperature Requirement A),...

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Identifiers

PMID: 26732659
DOI: 10.1038/srep18908
PMCID: PMC4702213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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