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Article

c-ets-1 DNA binding to the PEA3 motif is differentially inhibited by all the mutations found in v-ets.

Oncogene - 1 Jan 1992

Leprince D, Crepieux P, Stehelin D

Abstract excerpt

The proto-oncogene c-ets-1, one of the two cellular sequences transduced by the avian retrovirus E26, encodes for two transcription factors that activate through a purine-rich motif. The v-ets oncogene differs from its cellular progenitor p68c-ets-1 (i) by its fusion to gag- and myb-derived sequences in the E26 P135gag-myb-ets fusion protein, (ii) by two point mutations, and (iii) by the replacement of the 13...

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PMID: 1741168

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