Article
Conditional cell transformation by doxycycline-controlled expression of the MC29 v-myc allele.
Virology - 20 Jan 1999
Oberst C, Hartl M, Weiskirchen R, Bister K
Abstract excerpt
To investigate the molecular basis of oncogenesis induced by the v-myc oncogene of avian myelocytomatosis virus MC29, we developed a conditional cell transformation system in which expression of the MC29 v-myc allele is dependent on a doxycycline-sensitive transactivator (tTA). Clonal lines of quail embryo fibroblasts transformed by doxycycline-controlled v-myc revert to the normal phenotype and lose their...
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