Article
Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus.
Journal of virology - 1 Feb 1996
Fulton R, Gallagher R, Crouch D, Neil J C
Abstract excerpt
The T17 v-myc oncogene was transduced by feline leukemia virus in a spontaneous feline T-cell lymphosarcoma. Molecular cloning and sequencing of the v-myc gene revealed several unique mutations, including a large deletion affecting amino acids 49 to 124 and a 3-bp insertion within the basic DNA b...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Base Sequence
- Basic-Leucine Zipper Transcription Factors
- Binding Sites
- Cats
- Cell Transformation, Viral
- DNA-Binding Proteins
- Fibroblasts
- Genes, myc
- Leukemia Virus, Feline
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins c-myc
- Transcription Factors
- Transduction, Genetic
- Tumor Cells, Cultured