Article
The DNA supercoiling architecture induced by the transcription factor xUBF requires three of its five HMG-boxes.
Nucleic acids research - 15 Aug 1996
Stefanovsky V Y, Bazett-Jones D P, Pelletier G, Moss T
Abstract excerpt
The formation of a near complete loop of DNA is a striking property of the architectural HMG-box factor xUBF. Here we show that DNA looping only requires a dimer of Nbox13, a C-terminal truncation mutant of xUBF containing just HMG-boxes 1-3. This segment of xUBF corresponds to that minimally req...
Topics
- Binding Sites
- DNA Footprinting
- DNA, Superhelical
- Electrons
- High Mobility Group Proteins
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- Sequence Deletion
- Spectrum Analysis
- Structure-Activity Relationship