Article
Eukaryotic HMGB proteins as replacements for HU in E. coli repression loop formation.
Nucleic acids research - 1 Jul 2008
Becker Nicole A, Kahn Jason D, Maher L James
Abstract excerpt
DNA looping is important for gene repression and activation in Escherichia coli and is necessary for some kinds of gene regulation and recombination in eukaryotes. We are interested in sequence-nonspecific architectural DNA-binding proteins that alter the apparent flexibility of DNA by producing transient bends or kinks in DNA. The bacterial heat unstable (HU) and eukaryotic high-mobility group B (HMGB) proteins...
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