Article
The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.
Molecular and cellular biology - 1 Jun 2002
Mitsouras Katherine, Wong Ben, Arayata Charina, Johnson Reid C, Carey Michael
Abstract excerpt
HMGB1 (also called HMG-1) is a DNA-bending protein that augments the affinity of diverse regulatory proteins for their DNA sites. Previous studies have argued for a specific interaction between HMGB1 and target proteins, which leads to cooperative binding of the complex to DNA. Here we propose a different model that emerged from studying how HMGB1 stimulates enhanceosome formation by the Epstein-Barr viral...
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