Article
Induction of beta-MHC transgene in overloaded skeletal muscle is not eliminated by mutation of conserved elements.
The American journal of physiology - 1 Aug 1996
Tsika G L, Wiedenman J L, Gao L, McCarthy J J, Sheriff-Carter K, Rivera-Rivera I D, Tsika R W
Abstract excerpt
Mechanical overload leads to hypertrophy, increased type I fiber composition, and beta-myosin heavy chain (beta-MHC) induction in the fast-twitch plantaris muscle. To better understand the mechanism(s) involved in beta-MHC induction, we have examined inducible expression of transgenes carrying the simultaneous mutation of three DNA regulatory subregions [muscle CAT (MCAT), C-rich, and beta e3] in the context of...
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