Article
Induction of beta-MHC transgene in overloaded skeletal muscle is not eliminated by mutation of conserved elements.
The American journal of physiology - 1 Aug 1996
Tsika G L, Wiedenman J L, Gao L, McCarthy J J, Sheriff-Carter K, Rivera-Rivera I D, Tsika R W
Abstract excerpt
Mechanical overload leads to hypertrophy, increased type I fiber composition, and beta-myosin heavy chain (beta-MHC) induction in the fast-twitch plantaris muscle. To better understand the mechanism(s) involved in beta-MHC induction, we have examined inducible expression of transgenes carrying th...
Topics
- Animals
- Body Weight
- Chloramphenicol O-Acetyltransferase
- Conserved Sequence
- Gene Dosage
- Gene Expression Regulation
- Mice
- Mice, Transgenic
- Muscle Fibers, Skeletal
- Muscle, Skeletal
- Mutation
- Myosin Heavy Chains
- Organ Size
- Stress, Mechanical
- Time Factors
- Transgenes