Article
Transgenic analysis of the thyroid-responsive elements in the alpha-cardiac myosin heavy chain gene promoter.
The Journal of biological chemistry - 25 Feb 1993
Subramaniam A, Gulick J, Neumann J, Knotts S, Robbins J
Abstract excerpt
The role of two putative, cis-acting thyroid hormone-responsive elements, TRE1 and TRE2, located at -129 to -149 and -102 to -120, respectively, on the murine alpha-myosin heavy chain (MHC) gene, has been investigated in transgenic mice. These motifs are present in a 4.5-kilobase fragment lying upstream of the transcriptional start site of the mouse alpha-MHC gene: this fragment directs appropriate expression of...
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