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Article

Transgenic mice with a mutated collagen promoter display normal response during bleomycin-induced fibrosis and possess neurological abnormalities.

Journal of cellular biochemistry - 1 Feb 2000

Stoddart J H, Ladd D, Bronson R T, Harmon M, Jaworski J, Pritzker C, Lausen N, Smith B D

Abstract excerpt

We have previously identified a potential TGF-beta activation element (TAE) in the rat collagen alpha1(I) promoter at -1624 upstream of the transcriptional start site [Ritzenthaler et al., 1991, 1993]. To determine the importance of the TAE in vivo, we produced transgenic mice carrying 3.6 kb of the rat collagen alpha1(I) promoter linked to the reporter gene chloramphenicol acetyl transferase with and without...

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Source

Identifiers

PMID: 10679824
DOI: 10.1002/(sici)1097-4644(20000401)77:1<135::aid-jcb14>3.0.co;2-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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