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Article

Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.

The Journal of biological chemistry - 18 Jun 2004

Parsons Stephanie A, Millay Douglas P, Wilkins Benjamin J, Bueno Orlando F, Tsika Gretchen L, Neilson Joel R, Liberatore Christine M, Yutzey Katherine E, Crabtree Gerald R, Tsika Richard W, Molkentin Jeffery D

Abstract excerpt

The serine/threonine phosphatase calcineurin is an important regulator of calcium-activated intracellular responses in eukaryotic cells. In higher eukaryotes, calcium/calmodulin-mediated activation of calcineurin facilitates direct dephosphorylation and nuclear translocation of the transcription factor nuclear factor of activated T-cells (NFAT). Recently, controversy has surrounded the role of calcineurin in...

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Identifiers

PMID: 15082723
DOI: 10.1074/jbc.M313800200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.PMID 15082723Read ↗

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Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and FunctionSemantic proximity Read ↗

Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unloadSemantic proximity Read ↗

Matching of calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth.Semantic proximity Read ↗

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Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.Semantic proximity Read ↗

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