Article
Rare occurrence of p53 and ras gene mutations in preneoplastic and neoplastic mouse endometrial lesions induced by N-methyl-N-nitrosourea and 17 beta-estradiol.
Cancer letters - 8 Jun 1995
Murase T, Niwa K, Morishita S, Itoh N, Mori H, Tanaka T, Tamaya T
Abstract excerpt
To examine K-, H-, or N-ras and p53 gene mutations in mouse endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17 beta-estradiol, we performed polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) in 13 adenocarcinomas and 11 other preneoplastic lesions. A sig...
Topics
- Adenocarcinoma
- Animals
- Base Sequence
- Endometrial Neoplasms
- Endometrium
- Estradiol
- Exons
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Hyperplasia
- Methylnitrosourea
- Mice
- Mice, Inbred ICR
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction