Article
Binding properties of somatostatin receptor subtypes.
Metabolism: clinical and experimental - 1 Aug 1996
Bruns C, Raulf F, Hoyer D, Schloos J, Lübbert H, Weckbecker G
Abstract excerpt
In the past few years, five different somatostatin (SRIF) receptor subtypes (sst1.5) have been identified, which form a distinct group in the superfamily of G-protein-coupled receptors. The naturally occurring somatostatins SRIF-28, SRIF-25, and SRIF-14 all reveal high-affinity binding for sst1.5. In contrast, short synthetic analogs that are in clinical use, such as SMS 201-995, RC-160, or BIM 23014, primarily...
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