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Article

Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Apr 2008

Qiu Cuie, Zeyda Thomas, Johnson Brian, Hochgeschwender Ute, de Lecea Luis, Tallent Melanie K

Abstract excerpt

The K(+) M-current (I(M), Kv7) is an important regulator of cortical excitability, and mutations in these channels cause a seizure disorder in humans. The neuropeptide somatostatin (SST), which has antiepileptic properties, augments I(M) in hippocampal CA1 pyramidal neurons. We used SST receptor knock-out mice and subtype-selective ligands to investigate the receptor subtype that couples to I(M) and mediates the...

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Identifiers

PMID: 18385315
DOI: 10.1523/JNEUROSCI.4679-07.2008
PMCID: PMC6671094

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SST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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