Article
Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes.
The Journal of clinical endocrinology and metabolism - 1 Feb 2000
Jaquet P, Saveanu A, Gunz G, Fina F, Zamora A J, Grino M, Culler M D, Moreau J P, Enjalbert A, Ouafik L H
Abstract excerpt
Recently, studies using somatostatin (SRIF) analogs preferential for either the SRIF receptor 2 (SSTR2) or the SSTR5 subtype demonstrated a variable suppression of GH and PRL release from GH-secreting human adenomas. These data suggested the concept of SSTR subtype specificity in such tumors. In the present study the quantitative expression of messenger ribonucleic acid (mRNA) for the 5 SSTR subtypes and the...
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