Agonist-independent internalization and activity of a C-terminally truncated somatostatin receptor subtype 2 (delta349).

doi:10.1046/j.1471-4159.1999.0721275.x

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Article

Agonist-independent internalization and activity of a C-terminally truncated somatostatin receptor subtype 2 (delta349).

Journal of neurochemistry - 1 Mar 1999

Schwartkop C P, Kreienkamp H J, Richter D

Abstract excerpt

The rat somatostatin receptor subtype 2 (SSTR2) is rapidly internalized and phosphorylated in the presence of somatostatin 14 (SST14). Several C-terminal deletion constructs of SSTR2 have been investigated for their ability to undergo agonist-dependent internalization by using biochemical ligand binding assays and confocal microscopic analysis. Whereas mutant receptors lacking either 10 (delta359), 30 (delta339),...

Topics

Amino Acid Sequence
Animals
Cell Line
Cyclic AMP
Humans
Kidney
Microscopy, Confocal
Molecular Sequence Data
Mutation
Oocytes
Peptide Fragments
Phosphorylation
Rats
Receptors, Somatostatin
Somatostatin
Xenopus laevis

Source

Open in PubMed

Identifiers

PMID: 10037501
DOI: 10.1046/j.1471-4159.1999.0721275.x

Genes

SSTR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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