Article
Agonist-independent internalization and activity of a C-terminally truncated somatostatin receptor subtype 2 (delta349).
Journal of neurochemistry - 1 Mar 1999
Schwartkop C P, Kreienkamp H J, Richter D
Abstract excerpt
The rat somatostatin receptor subtype 2 (SSTR2) is rapidly internalized and phosphorylated in the presence of somatostatin 14 (SST14). Several C-terminal deletion constructs of SSTR2 have been investigated for their ability to undergo agonist-dependent internalization by using biochemical ligand binding assays and confocal microscopic analysis. Whereas mutant receptors lacking either 10 (delta359), 30 (delta339),...
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