Immunohistochemical localization of the somatostatin sst2(b) receptor splice variant in the rat central nervous system.

doi:10.1016/s0306-4522(98)00483-7

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Article

Immunohistochemical localization of the somatostatin sst2(b) receptor splice variant in the rat central nervous system.

Neuroscience - 1 Mar 1999

Schindler M, Humphrey P P, Löhrke S, Friauf E

Abstract excerpt

Somatostatin is a neuromodulator in the mammalian CNS. To date, genes for at least five different somatotrophin release inhibiting factor receptors, termed sst1-sst5, have been cloned. The rat sst2 receptor exists in two splice variants, sst(alpha)a) and sst2(b), which differ in their carboxy-termini. When heterologously expressed in Chinese hamster ovary-K1 cells, these splice variants show little difference in...

Topics

Animals
Blotting, Western
CHO Cells
Central Nervous System
Cricetinae
DNA, Recombinant
Genetic Variation
Humans
Immunohistochemistry
Rats
Receptors, Somatostatin
Tissue Distribution

Source

Open in PubMed

Identifiers

PMID: 10218786
DOI: 10.1016/s0306-4522(98)00483-7

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