Article
C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1999
Sharma K, Patel Y C, Srikant C B
Abstract excerpt
Ligand-activated somatostatin receptors (SSTRs) initiate cytotoxic or cytostatic antiproliferative signals. We have previously shown that cytotoxicity leading to apoptosis was signaled solely via human (h) SSTR subtype 3, whereas the other four hSSTR subtypes initiated a cytostatic response that led to growth inhibition. In the present study we characterized the antiproliferative signaling mediated by hSSTR...
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