Article
C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1999
Sharma K, Patel Y C, Srikant C B
Abstract excerpt
Ligand-activated somatostatin receptors (SSTRs) initiate cytotoxic or cytostatic antiproliferative signals. We have previously shown that cytotoxicity leading to apoptosis was signaled solely via human (h) SSTR subtype 3, whereas the other four hSSTR subtypes initiated a cytostatic response that...
Topics
- Animals
- CHO Cells
- Cricetinae
- Cytosol
- G1 Phase
- GTP-Binding Proteins
- Hormones
- Humans
- Membrane Proteins
- Mutation
- Octreotide
- Phosphorylation
- Protein Tyrosine Phosphatase, Non-Receptor Type 1
- Protein Tyrosine Phosphatases
- Receptors, Somatostatin
- Retinoblastoma Protein
- Somatostatin
- Virulence Factors, Bordetella