Article
A single amino acid substitution in somatostatin receptor subtype 5 increases affinity for somatostatin-14.
Molecular pharmacology - 1 Jan 1995
Ozenberger B A, Hadcock J R
Abstract excerpt
Four of the five somatostatin receptor (SSTR) subtypes bind the two native forms of somatostatin, i.e., somatostatin-14 (S-14) and amino-terminally extended somatostatin-28 (S-28), with comparable affinities (approximately 0.2 nM). The SSTR5 subtype exhibits 10-50-fold higher affinity for S-28 than for S-14 (0.2 and 5 nM, respectively). To determine which domains in SSTR5 are responsible for the observed...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA, Complementary
- Kinetics
- Macromolecular Substances
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation