Structural properties and mutation patterns of anti-nucleosome monoclonal antibodies are similar to those of anti-DNA antibodies.

doi:10.1002/eji.1830260727

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Article

Structural properties and mutation patterns of anti-nucleosome monoclonal antibodies are similar to those of anti-DNA antibodies.

European journal of immunology - 1 Jul 1996

Brard F, Jovelin F, Petit S, Tron F, Gilbert D

Abstract excerpt

Four monoclonal antibodies (mAb) derived from an (NZB x NZW)F1 mouse bound to nucleosomes, total histones and to the H2A-H2B dimers but not to individual histones or DNA. Sequencing of their heavy (H)- and light (L)-chain variable region genes showed that they derived by somatic mutations from th...

Topics

Amino Acid Sequence
Animals
Antibodies, Antinuclear
Antibodies, Monoclonal
Antibody Specificity
Base Sequence
Biosensing Techniques
Computer Simulation
Crosses, Genetic
DNA
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulin Variable Region

Mice

Mice, Inbred NZB

Molecular Sequence Data

Mutation

Nucleosomes

Source

Open in PubMed

Identifiers

PMID: 8766565
DOI: 10.1002/eji.1830260727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8766565-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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