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Article

Generation of Monoclonal Antibodies against Highly Conserved Antigens

29 Jun 2009

Abstract excerpt

BACKGROUND: Therapeutic antibody development is one of the fastest growing areas of the pharmaceutical industry. Generating high-quality monoclonal antibodies against a given therapeutic target is very crucial for the success of the drug development. However, due to immune tolerance, some proteins that are highly conserved between mice and humans are not very immunogenic in mice, making it difficult to generate...

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PMID: 19564921
DOI: 10.1371/journal.pone.0006087

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