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Article

Molecular hallmarks of anti-chromatin antibodies associated with the lupus susceptibility locus, Sle1.

Molecular immunology - 1 Aug 2009

Liang Zhiyan, Chang Sooghee, Youn Min So, Mohan Chandra

Abstract excerpt

Anti-nuclear antibodies constitute the hallmark of lupus. The NZM2410-derived Sle1 lupus susceptibility interval on murine chromosome 1 breaches tolerance, leading to the emergence of anti-nuclear autoantibodies targeting nucleosomes. However, little is known about the molecular structure of the anti-nucleosome autoantibodies from this genetically simplified mouse model of lupus. In this study, the immunoglobulin...

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Source

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Identifiers

PMID: 19556006
DOI: 10.1016/j.molimm.2008.12.034
PMCID: PMC2886130

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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