Article
Collagen type I enhances endothelin-mediated contraction and induces nonproliferating phenotype in mesangial cells.
The American journal of physiology - 1 Jun 1996
Miralem T, Whiteside C I, Templeton D M
Abstract excerpt
Accumulation of glomerular extracellular matrix is a characteristic accompaniment of mesangial cell proliferation in progressive renal disease. We examined how growth on several matrices affected the proliferative phenotype of cultured rat mesangial cells. Compared with growth on plastic, Matrigel, or mesangial matrix, collagen type I caused a decreased cell number at 72 h, decreased total DNA per culture, and a...
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