Collagen type I enhances endothelin-mediated contraction and induces nonproliferating phenotype in mesangial cells.

doi:10.1152/ajprenal.1996.270.6.F960

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Article

Collagen type I enhances endothelin-mediated contraction and induces nonproliferating phenotype in mesangial cells.

The American journal of physiology - 1 Jun 1996

Miralem T, Whiteside C I, Templeton D M

Abstract excerpt

Accumulation of glomerular extracellular matrix is a characteristic accompaniment of mesangial cell proliferation in progressive renal disease. We examined how growth on several matrices affected the proliferative phenotype of cultured rat mesangial cells. Compared with growth on plastic, Matrige...

Topics

Alkaloids
Animals
Calcium
Carbazoles
Cell Division
Collagen
Endothelins
Glomerular Mesangium
Indoles
Male
Myosin Light Chains
Phenotype
Phosphorylation
Rats
Rats, Wistar
Signal Transduction
Solubility

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