Article
Modification of type I collagenous gels by alveolar epithelial cells.
American journal of respiratory cell and molecular biology - 1 Jun 2000
Umino T, Wang H, Zhu Y, Liu X, Manouilova L S, Spurzem J R, Patricia Leuschen M, Rennard S I
Abstract excerpt
Contraction of type I collagen gels is an in vitro model of tissue remodeling. In addition to fibroblasts, some epithelial cells can mediate this process. We therefore hypothesized that alveolar epithelial cells might contract extracellular matrices and have the potential to directly participate in the remodeling of the lung after alveolar injury. A549 cells were plated on top of collagen gels, and the gels were...
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