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Article

Phenotypic modifications of human mesangial cells by extracellular matrix: the importance of matrix in the contractile response to reactive oxygen species.

Experimental nephrology - 1 Jan 2000

Iglesias-De La Cruz M C, Ruiz-Torres M P, De Lucio-Cazaña F J, Rodríguez-Puyol M, Rodríguez-Puyol D

Abstract excerpt

The progression of chronic renal diseases is characterized by the accumulation of extracellular matrix proteins in the glomerulus. The present experiments were designed to analyze the effect of hydrogen peroxide on the contractile and proliferative phenotypes of human mesangial cells grown on different culture substrates: plastic, collagen type I, and collagen type IV. Contraction was analyzed by measuring planar...

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Identifiers

PMID: 10729749
DOI: 10.1159/000020655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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