Restoration to a quiescent and contractile phenotype from a proliferative phenotype of myofibroblast-like human aortic smooth muscle cells by culture on type IV collagen gels.

Abstract excerpt

Aortic smooth muscle cells (A-SMC) undergo phenotypic transition to a synthetic and proliferative state and become fibroblast-like cells upon serial passage with culture on plastic dishes, especially in the presence of serum. Such fibroblast-like cells (M-SMC) derived from A-SMC may correspond to the cells identified pathologically as myofibroblasts. We examined the effects of type IV collagen gels used as a...

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