Restoration to a quiescent and contractile phenotype from a proliferative phenotype of myofibroblast-like human aortic smooth muscle cells by culture on type IV collagen gels.

doi:10.1093/oxfordjournals.jbchem.a022407

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Restoration to a quiescent and contractile phenotype from a proliferative phenotype of myofibroblast-like human aortic smooth muscle cells by culture on type IV collagen gels.

Journal of biochemistry - 1 Jun 1999

Hirose M, Kosugi H, Nakazato K, Hayashi T

Abstract excerpt

Aortic smooth muscle cells (A-SMC) undergo phenotypic transition to a synthetic and proliferative state and become fibroblast-like cells upon serial passage with culture on plastic dishes, especially in the presence of serum. Such fibroblast-like cells (M-SMC) derived from A-SMC may correspond to the cells identified pathologically as myofibroblasts. We examined the effects of type IV collagen gels used as a...

Topics

Animals
Cattle
Cell Division
Cell Size
Cells, Cultured
Collagen
Culture Media
Fibroblasts
Gels
Humans
Muscle, Smooth, Vascular
Phenotype

Source

Open in PubMed

Identifiers

PMID: 10348898
DOI: 10.1093/oxfordjournals.jbchem.a022407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics