Extracellular matrix phenotype of rat mesangial cells in culture. Biosynthesis of collagen types I, III, IV, and V and a low molecular weight collagenous component and their regulation by dexamethasone.

Abstract excerpt

Rat glomerular cells were cultured in vitro to evaluate their collagen phenotype. The enriched epithelial cell population that grew out from glomeruli in the initial stages of culture primarily synthesized type IV collagen. By 14 days, mesangial cell proliferation occurred with a coordinate change in collagen phenotype, after which time these cells mainly synthesized type I collagen and lesser amounts of types...

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