Article
Malignant conversion of human cells by antisense cDNA to a putative tumor suppressor gene.
Carcinogenesis - 1 Aug 1996
Li D, Yan H, Chen J, Casto B C, Theil K S, Milo G E
Abstract excerpt
A cell line, SCC83-01-82, derived from a human oral squamous carcinoma, was non-tumorigenic in nude mice, a characteristic of premalignant cells. Conversion of these cells to a tumorigenic phenotype with chemical mutagens did not increase mutations in hot spots or other conserved regions of p53 o...
Topics
- Animals
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Chromosomes, Human, Pair 7
- DNA Probes
- DNA, Antisense
- DNA, Complementary
- Genes, Tumor Suppressor
- Genes, p53
- Genes, ras
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mouth Neoplasms
- Phenotype