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Article

Generation of metastatic variants by transfection of a nonmetastatic rat mammary epithelial cell line with DNA from a metastatic rat mammary cell line.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1990

Jamieson S, Barraclough R, Rudland P S

Abstract excerpt

Transfection of rat mammary (Rama) 37 epithelial cells, which yield nonmetastasizing adenomas in syngeneic Wistar-Furth rats, with HindIII-fragmented cellular DNA and the drug-resistance plasmids pSV2gpt or pSV2neo yields drug-resistant transformants with a frequency of 10(-4)-10(-5). Transformant cell lines transfected with the following, pSV2gpt alone, pSV2gpt and Rama 37 DNA, pSV2gpt and DNA from a...

Topics

Animals
Cell Line
DNA, Neoplasm
Drug Resistance
Female
Genetic Variation
Mammary Neoplasms, Experimental
Neoplasm Metastasis
Phenotype
Plasmids
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred WF

Transfection

Source

Identifiers

PMID: 2078312
DOI: 10.1159/000163605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2078312-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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