Article
A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.
2 Aug 1994
Abstract excerpt
As an approach to identify human oncogenes, we generated an expression cDNA library from an ovarian carcinoma line. A potent transforming gene was detected by transfection analysis and identified as TC21, a recently cloned member of the RAS gene superfamily. A single point mutation substituting glutamine for leucine at position 72 was shown to be responsible for activation of transforming properties. While the...
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