Article
Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A/J mice.
Toxicology - 28 Dec 1995
Nesnow S, Ross J A, Stoner G D, Mass M J
Abstract excerpt
Five polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F), dibenz[a,h]anthracene (DBA), 5-methylchyrsene (5MC), and cyclopenta[cd]pyrene (CPP) were examined for their lung tumorigenic activities in strain A/J mice, their ability to form PAH-DNA adducts in...
Topics
- Adenoma
- Animals
- Base Sequence
- Biotransformation
- Carcinogens
- DNA Adducts
- Genes, ras
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred A
- Molecular Sequence Data
- Mutation
- Neoplasms
- Polycyclic Aromatic Hydrocarbons
- Polymerase Chain Reaction
- Structure-Activity Relationship